As a teaser, I am in receipt of several interesting emails from genetics researchers concerning the Guillain-Barre’ spectrum. Yes, Guillain-Barre’ has been promoted from a mere syndrome to a group of syndromes. So far, no clearly implicated genes, but several “genes of interest”. And a book about whether Franklin Roosevelt was misdiagnosed with polio in 1921. Unfortunately, if he really had Guillain-Barre’ it is not clear what else or what more could have been done for him (or anyone else) back then. Alas, after nearly 100 years it is not obvious that diagnostic methods are widely applied or that there is a treatment for each of the various syndromes.