, , , ,

Back in January the FOXP2 gene on chromosome 7 at location q31.1 was mentioned as having multiple significantly different mutations as well as deletions, translocations and disomies. The FOXP2-related speech and language disorder was mentioned in passing. From a presentation done for New Zealand: The FOXP2 gene on chromosome 7 is somewhat controversial. Part of the confusion is that it matters whether the gene has a mutation (there are at least two significantly different ones), a micro-deletion, a repeat
or is trans-located. FOXP2 is normally located in the q31.1 region – a translocation to the q22 region causes a condition known as developmental verbal dyspraxia (DVD). Both a missense mutation causing an arginine-to-histidine substitution (R553H) and a nonsense
mutation (R328X) causing a truncated protein cause speech and language difficulties. FOXP2 also regulates at least the following genes: SRPX2 (work underway); CNTNAP2  and CTBP1.  CNTNAP2 interacts with CNTN2.  CNTN2 interacts with the NFYB gene
which interacts with three more genes. Of those, CEBPZ interacts with 2 other genes, myc with 37 other genes and TBP with 27 other genes. 

CTBP1 interacts with 14 other genes. The second generation of interactions with the CTBP1 gene now includes over 160 other genes.

So far, 188 genes linked to FOXP2.