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I was e-chatting with three genetics researchers in Scotland, Belarus and Slovakia about some changes being made to the HERON application. HERON tracks personal food and drink consumption, sleep and reactions in just about molecular detail. I had imposed some structure on the diary entries: in particular, I had segregated sleep text. I was asked  if HERON was intending to help people determine if they have a genetic challenge in the area of sleep. One thing led to another (as they often do) so now the databases used by the SAITO and HERON applications are richer by 6 syndromes and 27 genes. Note that these genes are infamous primarily for disrupting sleep – there are plenty of syndromes and genes, especially in the autism and epilepsy-aphasia spectra that include sleep problems among their symptoms. Here’s the list so far

1,p36.22,TNFRSF1B,Narcolepsy
1,p36.23,PER3,Advanced sleep phase syndrome familial 3 (FASPS3)
2,p14,MEIS1,Restless legs syndrome
2,q11.2,NPAS2,seasonal affective disorder
2,q37.3,PER2,seasonal affective disorder
4,q12,CLOCK,seasonal affective disorder
6,p21.2,BTBD9,Restless legs syndrome
6,p21.32,HLA-DQA1,Narcolepsy
6,p21.32,HLA-DQB1,Narcolepsy
6,p21.32,HLA-DRB1,Narcolepsy
6,p21.33,TNF,Narcolepsy
9,p24.1,PTPRD,Restless legs syndrome
10,q23.2,OPN4,seasonal affective disorder
11,p11.2,CRY2,seasonal affective disorder
11,p15.3,ARNTL,seasonal affective disorder
12,p12.1,BHLHE41,seasonal affective disorder
12,q23.3,CRY1,Sleep-wake schedule disorder – delayed phase type
13,q14.2,HTR2A,seasonal affective disorder
14,q11.2,TRA,Narcolepsy
15,q23,MAP2K5,Restless legs syndrome
15,q23,SKOR1,Restless legs syndrome
16,q12.1,TOX3,Restless legs syndrome
17,p11.2,RAI1,Circadian rhythm disruption
17,q21.2,HCRT,Narcolepsy
17,q25.1,AANAT,Sleep-wake schedule disorder – delayed phase type
22,q13.33,CHKB,Narcolepsy
22,q13.33,CPT1B,Narcolepsy

 

 

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