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who in 1967 published a short story titled “I Have No Mouth and I Must Scream”. It won a Hugo Award in 1968. I am pretty certain it was not the author’s intent, but the title does sum up some aspects of an autistic person’s life. What brought it to mind was recent analysis of the genetics of cleft lip and cleft palate. Both conditions are serious and tragic – even wanting to express the most basic human expression –  smile – is difficult.

A cynic would suggest that the presence of cleft palate and cleft lip genes on 21 of 23 chromosomes probably means genes 17 and 21 need to be studied more closely. 69 genes so far!?