, , , , ,

Mr Bond, they have a saying in Chicago: “Once is happenstance. Twice is coincidence. The third time it’s enemy action.”
said by Auric Goldfinger in Ian Fleming’s novel, Goldfinger

Over 100 genes on 23 chromosomes can cause something like autism.

I don’t know (yet) how often someone with autism also has heartbeat problems. There are at least two challenges here: bradycardia when your heart slows down down to 60 or fewer beats a minute AND tachycardia when your heart speeds up to 100 or more beats per minute. Both are dangerous. So just being around people who might exhibit these conditions, let alone teaching them tai chi chuan, is somewhat difficult. It is fondly hoped that people with either cardia (autistic or not) would be wearing a smart watch, and someone nearby would be able to preempt somehow  before the heartbeat varies too far from 72.

But there’s another problem.

Suppose someone was autistic because there was a multi-gene deletion. If they were autistic and had paroxysmal tachycardia it would be reasonable to guess that one of the other genes deleted was involved in heartbeat. But the vast majority of reported bradycardia and tachycardia problems are single gene mutations. And none of them seem to be especially close to autism genes.

Sure, you have to be really unlucky to be autistic in the first place. So far, there are 22 genes on 13 chromosomes that are linked to bradycardia and 35 genes on 16 chromosomes that are linked to tachycardia. If tachycardia or bradycardia were truly independent of autism there shouldn’t be a difference of incidence between autistic and neurotypical populations.

No evidence of master genes that control other disparate genes. Maybe methylization or some epigenetic is involved. If not, something is seriously wrong. So what is the enemy?